After Guidobaldo’s death in 1508, he remained in the service of the new Duke, Francesco Maria della Rovere, becoming, in 1513, resident ambassador in Rome. In 1515 the expulsion of Francesco Maria from Urbino deprived him of a job, and in the years 1516-19 he lived quietly on his estates near Mantua. His major work is The Book of the Courtier. He also wrote a small number of excellent poems both in Latin and Italian. In 1519 he returned to Rome, as Mantuan ambassador, and after further activities on behalf of his Mantuan masters entered Papal service in 1524. From that date until his death in 1592 he was Papal Nuncio in Spain.